Potential Use of Pulsed Electromagnetic Field in Musculoskeletal Disorders: A Narrative Review
DOI:
https://doi.org/10.36570/jduhs.2024.1.1703Keywords:
Electromagnetic Field, Low Back Pain, Musculoskeletal Diseases, OsteoarthritisAbstract
Numerous studies conducted in the last few years have produced figures showing that the incidence of musculoskeletal issues is continuously rising and that a variety of treatment options are available. Musculoskeletal illnesses, including fractures, arthritis, and osteoporosis, are increasingly treated with electromagnetic fields (EMFs). As a non-invasive, secure, and efficient treatment tool with no apparent side effects, Pulsed Electromagnetic field (PEMF) are well recognized. The present study aims to evaluate the literature by reviewing the data already available on PEMF's effectiveness in the treatment of different musculoskeletal disorders. For locating the literature, articles published in English language on various musculoskeletal diseases treated by PEMFs were included. Information was looked for in the databases of PubMed, Google Scholar, Cochrane, and SCOPUS. The result of the study shows that due to its great efficacy and few risk considerations, PEMF has a lot of potentials to become a separate or complementary treatment strategy for treating numerous musculoskeletal disorders. The present study concludes that numerous issues are still unresolved. Further research from well-designed, high-quality studies are required to standardise therapy parameters and identify the most effective process for healthcare decision-making prior to widespread clinical application. In this study, we aim to provide up-to-date details on the therapeutic applications, mechanism of action, and ethical issues surrounding PEMFs in musculoskeletal disorders.
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References
Markov MS. Pulsed electromagnetic field therapy hist-ory, state of the art and future. The Environmentalist 2007; 27:465-75.
doi:10.1007/s10669-007-9128-2
Yasuda I. Fundamental aspects of fracture treatment. J Kyoto Med Soc 1953; 4:395-406.
Daish C, Blanchard R, Fox K, Pivonka P, Pirogova E. The Application of Pulsed Electromagnetic Fields (PEMFs) for bone fracture repair: past and perspective findings. Ann Biomed Eng 2018; 46:525-42. doi:10.1007/s10439-018-1982-1
Bassett CA, Pawluk RJ, Becker RO. Effects of electric currents on bone in vivo. Nature 1964; 204:652-4. doi:10.1038/204652a0
Paolucci T, Pezzi L, Centra AM, Giannandrea N, Bellomo RG, Saggini R. Electromagnetic field therapy: a rehabilitative perspective in the management of musculoskeletal pain - a systematic review. J Pain Res 2020; 13:1385-1400. doi:10.2147/JPR.S231778
Wang T, Yang L, Jiang J, Liu Y, Fan Z, Zhong C, et al. Pulsed electromagnetic fields: promising treatment for osteoporosis. Osteoporos Int 2019; 30:267-76. doi:10.1007/s00198-018-04822-6
Barnes FS, Greenebaum B. Handbook of Biological Effe-cts of Electromagnetic Fields-Two Volume Set. 3rd ed. CRC Press; 2018.
Yuan J, Xin F, Jiang W. Underlying signaling pathways and therapeutic applications of pulsed electromagnetic fields in bone repair. Cell Physiol Biochem 2018; 46:1581-94. doi:10.1159/000489206
Strauch B, Herman C, Dabb R, Ignarro LJ, Pilla AA. Evidence-based use of pulsed electromagnetic field therapy in clinical plastic surgery. Aesthet Surg J 2009; 29:135-43. doi:10.1016/j.asj.2009.02.001
Funk RH. Coupling of pulsed electromagnetic fields (PEMF) therapy to molecular grounds of the cell. Am J Transl Res 2018; 10:1260-72.
Kubat NJ, Moffett J, Fray LM. Effect of pulsed electromagnetic field treatment on programmed resolution of inflammation pathway markers in human cells in culture. J Inflamm Res 2015; 8:59-69. doi:10.2147/JIR.S78631
Ma KC, Baumhauer JF. Pulsed electromagnetic field treatment in wound healing. Current Orthop Practice 2013; 24:487-92.
Ferrigno B, Bordett R, Duraisamy N, Moskow J, Arul MR, Rudraiah S, et al. Bioactive polymeric materials and electrical stimulation strategies for musculoskeletal tissue repair and regeneration. Bioact Mater 2020; 5:468-85. doi:10.1016/j.bioactmat.2020.03.010
Hu H, Yang W, Zeng Q, Chen W, Zhu Y, Liu W, et al. Promising application of Pulsed Electromagnetic Fields (PEMFs) in musculoskeletal disorders. Biomed Pharmacother 2020; 131:110767. doi:10.1016/j.biopha.2020.110767
Vicenti G, Bizzoca D, Nappi VS, Moretti F, Carrozzo M, Belviso V, et al. Biophysical stimulation of the knee with PEMFs: from bench to bedside. J Biol Regul Homeost Agents 2018; 32: 23-8.
Giombini A, Di Cesare A, Quaranta F, Giannini S, Di Cagno A, Mazzola C, et al. Neck balance system in the treatment of chronic mechanical neck pain: a prospective randomized controlled study. Eur J Phys Rehabil Med 2013; 49:283-90.
de Freitas DG, Marcondes FB, Monteiro RL, Rosa SG, Fucs PM, Fukuda TY. Pulsed electromagnetic field and exercises in patients with shoulder impingement syndrome: a randomized, double-blind, placebo-controlled clinical trial. Arch Phys Med Rehabil 2014; 95:345-52. doi:10.1016/j.apmr.2013.09.022
Zhou J, Liao Y, Xie H, Liao Y, Liu H, Zeng Y, et al. Pulsed electromagnetic field ameliorates cartilage degeneration by inhibiting mitogen-activated protein kinases in a rat model of osteoarthritis. Phys Ther Sport 2017; 24:32-8. doi:10.1016/j.ptsp.2016.10.003
Sutbeyaz ST, Sezer N, Koseoglu F, Kibar . Low-frequency pulsed electromagnetic field therapy in fibromyalgia: a randomized, double-blind, sham-controlled clinical study. Clin J pain 2009; 25:722-8. doi:10.1097/AJP.0b013e3181a68a6c
Multanen J, Hakkinen A, Heikkinen P, Kautiainen H, Mustalampi S, Ylinen J. Pulsed electromagnetic field therapy in the treatment of pain and other symptoms in fibromyalgia: A randomized controlled study. Bioelectromagnetics 2018; 39:405-13.
doi:10.1002/bem.22127
Kanat E, Alp A, Yurtkuran M. Magnetotherapy in hand osteoarthritis: a pilot trial. Complement Ther Med
; 21:603-8. doi:10.1016/j.ctim.2013.08.004
Omar AS, Awadalla MA, El Latif MA. Evaluation of pul-sed electromagnetic field therapy in the management of patients with discogenic lumbar radiculopathy. Int J Rheum Dis 2012; 15:e101-8.
doi:10.1111/j.1756-185X.2012.01745.x
Oke KI, Umebese PF. Evaluation of the efficacy of pul-sed electromagnetic therapy in the treatment of back pain: a randomized controlled trial in a tertiary hospital in Nigeria. West Indian Med J 2013; 62:205-9.
Park WH, Sun SH, Lee SG, Kang BK, Lee JS, Hwang DG, et al. Effect of pulsed electromagnetic field treatment on alleviation of lumbar myalgia; a single center, randomized, double-blind, sham-controlled pilot trial study. J Magnetics 2014; 19:161-9.
Iammarrone CS, Cadossi M, Sambri, Grosso E, Corrado B, Servodio Iammarrone F. Is there a role of pulsed electromagnetic fields in management of patellofemoral pain syndrome? Randomized controlled study at one year follow-up. Bioelectroma-gnetics 2016; 37:81-8. doi:10.1002/bem.21953
Victoria G, Petrisor B, Drew B, Dick D. Bone stimulation for fracture healing: What's all the fuss? Indian J Orthop 2009; 43:117-20.
doi:10.4103/0019-5413.50844
Massari L, Benazzo F, Falez F, Perugia D, Pietrogrande L, Setti S, et al. Biophysical stimulation of bone and cartilage: state of the art and future perspectives. Int Orthop 2019; 43:539-51. doi:10.1007/s00264-018-4274-3
Rutherford G, Lithgow B, Moussavi Z. Transcranial magnetic stimulation safety from operator exposure perspective. Med Biol Eng Comput 2020; 58:249-56. doi:10.1007/s11517-019-02084-w
Kanis JA, Cooper C, Rizzoli R, Reginster JY. Scientific Advisory Board of the European Society for Clinical and Economic Aspects of Osteoporosis (ESCEO) and the Committees of Scientific Advisors and National Societies of the International Osteoporosis Foundation (IOF). European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int 2019; 30:3-44. doi:10.1007/s00198-018-4704-5
Tabrah F, Hoffmeier M, Gilbert Jr F, Batkin S, Bassett CA. Bone density changes in osteoporosis‐prone women exposed to pulsed electromagnetic fields (PEMFs). J Bone Miner Res 1990; 5:437-42. doi:10.1002/jbmr.5650050504
Costantini E, Sinjari B, D'Angelo C, Murmura G, Reale M, Caputi S. Human gingival fibroblasts exposed to extremely low-frequency electromagnetic fields: in vitro model of wound-healing improvement. Int J Mol Sci 2019; 20:2108. doi:10.3390/ijms20092108
Massari L, Fini M, Cadossi R, Setti S, Traina G C. Biophysical stimulation with pulsed electromagnetic fields in osteonecrosis of the femoral head. J Bone Joint Surg Am 2006; 88:56-60. doi:10.2106/JBJS.F.00536
De Girolamo L, Stanco D, Galliera E, Vigano M, Colom-bini A, Setti S, et al. Low frequency pulsed electromagnetic field affects proliferation, tissue-specific gene expression, and cytokines release of human tendon cells. Cell Biochem Biophys 2013; 66:697-708.
doi:10.1007/s12013-013-9514-y
Barnes FS, Greenebaum B, editors. Biological and medical aspects of electromagnetic fields. 4th ed. CRC Press; 2018.
Singh S, Kapoor N. Health implications of electromagnetic fields, mechanisms of action, and research needs. Advance Biol 2014; 14:1-24. doi:10.1155/2014/198609
Panagopoulos DJ. Comparing DNA damage induced by mobile telephony and other types of man-made electromagnetic fields. Mutat Res Rev Mutat Res 2019; 781:53-62. doi:10.1016/j.mrrev.2019.03.00
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