Hypothyroidism Increases Body Weight, Absolute and Relative Weight of Pituitary Gland in Male Albino Rats

Authors

  • Khalida Perveen Department of Anatomy, Dow International Medical College, Dow University of Health Sciences, Karachi, Pakistan.
  • Zaheer Amjad Department of Anatomy, Dow International Medical College, Dow University of Health Sciences, Karachi, Pakistan.
  • Shamama Bashir Department of Pharmacology, Sindh Medical College, Dow University of Health Sciences, Karachi, Pakistan

Keywords:

Pituitary gland, hyperthyroidism, thyroid hormones, absolute weight, relative weight, albino rats

Abstract

Objective:

To evaluate the increase in body weight, absolute and relative weight of pituitary gland in experimental
hypothyroid male albino rat.

Design:

An experimental animal study.

Place:

Anatomy Department, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, Karachi.

Methods:

Thirty adult albino rats were selected for the study and divided into two groups. Group A served as control group and received injection normal saline 1 cc intraperitoneally daily for six weeks. Group B was treated group and received carbimazole in a dose of 6µgm/gm body weight intraperitoneally daily for eight weeks. Animals were weighed at the commencement and at the completion of treatment. Absolute weights of pituitary glands were recorded after the animals were sacrificed. Relative weights of pituitary glands were also calculated. The results were compared with control and correlated with the previous studies.

Results:

Final body weight of animals were increased significantly (P<0.001) in treated group (B) as compared to control group (A). Absolute weight of pituitary gland was significantly increased (P<0.001) in group B as compared to group A. Relative weight of   pituitary gland was significantly increased (P<0.001) in group B as compared to group A.

Conclusion:

There is increase in body weight of animals by the effect of  carbimazole. Enlargement of pituitary gland due to its hyperplasia results in increase in the absolute weight. The increase in generalized body weight results in increase in relative weight of the organ.

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References

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Published

2012-04-17

How to Cite

Perveen, K. ., Amjad, Z. ., & Bashir, S. . (2012). Hypothyroidism Increases Body Weight, Absolute and Relative Weight of Pituitary Gland in Male Albino Rats. Journal of the Dow University of Health Sciences (JDUHS), 6(1), 25–28. Retrieved from https://mail.jduhs.com/index.php/jduhs/article/view/1525

Issue

Vol. 6 No. 1

Section

Original Articles

License

Copyright (c) 2021 Khalida Perveen, Zaheer Amjad, Shamama Bashir

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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