Antihyperlipidemic effect of Adonis vernalis

Authors

  • Tooba Lateef Department of Biochemistry, Jinnah University for Women, Karachi, Pakistan
  • Anila Riaz Department of Biochemistry, Jinnah University for Women, Karachi, Pakistan
  • Anum Zehra Department of Biochemistry, Jinnah University for Women, Karachi, Pakistan
  • Shamim A Qureshi Department of Biochemistry, University of Karachi, Karachi, Pakis

Keywords:

Hyperlipidemia, Coronary artery disease, Cardiotonic, Cardiac glycoside, Diuretic, Antihyperlipidemic, Hepatoprotective

Abstract

Objective

To study the effect of Adonis vernalis on triton-induced hyperlipidemic rabbits. Hyperlipidemia has become a major risk factor for a large variety of diseases including coronary artery disease and thus increasing mortality ratio globally. A. vernalis (AV) commonly called as Pheasant eye is a Homoeopathic remedy and considered as cardiotonic due to presence of cardiac gylcosides with strong diuretic action.

Study Design & Methods

The present study investigates the hyperlipidemic effects of Adonis vernalis in chemically (triton; 400 mg/kg intraperitoneally) induced hyperlipidemic rabbits. Its effects on lipid profile, glucose, total protein, serum uric acid and liver specific enzyme alanine aminotransferase (ALT) were determined by administering alcoholic extract of A. vernalis (5 mg/kg) orally and compared against respective control groups.

Results

AV (5 mg/kg) had shown a significant decrease in serum cholesterol and triglycerides when compared with control, triton-induced hyperlipidemic control (TIC) and triton-induced positive control (TIPC) (p<0.05). It slightly increased HDL, clear decrease in LDL and total protein while no effect was found on ALT, uric acid and glucose.

Conclusions

According to the experimental findings the alcoholic extract of A. vernalis found to be a potent antihyperlipidemic agent and also showed hepatoprotective property.

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Published

2012-06-08

How to Cite

Lateef, T. ., Riaz, A. ., Zehra, A. ., & A Qureshi, S. . (2012). Antihyperlipidemic effect of Adonis vernalis. Journal of the Dow University of Health Sciences (JDUHS), 6(2), 47–51. Retrieved from https://mail.jduhs.com/index.php/jduhs/article/view/1503

Issue

Vol. 6 No. 2

Section

Original Articles

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Copyright (c) 2021 Tooba Lateef, Anila Riaz, Anum Zehra, Shamim A Qureshi

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