Antihyperlipidemic effect of Adonis vernalis

Authors

  • Tooba Lateef Department of Biochemistry, Jinnah University for Women, Karachi, Pakistan
  • Anila Riaz Department of Biochemistry, Jinnah University for Women, Karachi, Pakistan
  • Anum Zehra Department of Biochemistry, Jinnah University for Women, Karachi, Pakistan
  • Shamim A Qureshi Department of Biochemistry, University of Karachi, Karachi, Pakis

Keywords:

Hyperlipidemia, Coronary artery disease, Cardiotonic, Cardiac glycoside, Diuretic, Antihyperlipidemic, Hepatoprotective

Abstract

Objective

To study the effect of Adonis vernalis on triton-induced hyperlipidemic rabbits. Hyperlipidemia has become a major risk factor for a large variety of diseases including coronary artery disease and thus increasing mortality ratio globally. A. vernalis (AV) commonly called as Pheasant eye is a Homoeopathic remedy and considered as cardiotonic due to presence of cardiac gylcosides with strong diuretic action.

Study Design & Methods

The present study investigates the hyperlipidemic effects of Adonis vernalis in chemically (triton; 400 mg/kg intraperitoneally) induced hyperlipidemic rabbits. Its effects on lipid profile, glucose, total protein, serum uric acid and liver specific enzyme alanine aminotransferase (ALT) were determined by administering alcoholic extract of A. vernalis (5 mg/kg) orally and compared against respective control groups.

Results

AV (5 mg/kg) had shown a significant decrease in serum cholesterol and triglycerides when compared with control, triton-induced hyperlipidemic control (TIC) and triton-induced positive control (TIPC) (p<0.05). It slightly increased HDL, clear decrease in LDL and total protein while no effect was found on ALT, uric acid and glucose.

Conclusions

According to the experimental findings the alcoholic extract of A. vernalis found to be a potent antihyperlipidemic agent and also showed hepatoprotective property.

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References

Tan CY, Vidal-Puig A. The metabolic syndrome. Biochemist 2009; 31:14-18.

Holvoet P, Kritchevsky SB, Tracy RP. The metabolic syndrome, circulating oxidized LDL and risk of myocardial infarction in well-functioning elderly people in the health, aging and body composition. Diabetes 2004; 53:1068-73.

Repas T. Obesity and dyslipidemia. S D Med. 2011; 64:241-247.

Perreault S, Dorais M, Coupal L. Impact of treating hyperlipidemia or hypertension to reduce the risk of death from coronary artery disease. Canadian Medical Association Journal. 1999; 160:1449-55.

Abdelhalim MAK. The potential influence of high cholesterol diet induced oxidative stress on composition and properties of red blood cells in rabbits. African Journal of Microbiology Research. 2010;4: 836-43.

Balakumar P, Babbar L. Preconditioning the hyperlipidemic myocardium: fact or fantasy? Cell Signal. 2012; 24:589-95.

Kuklina EV, Keenan NL, Callaghan WM. Risk of cardiovascular mortality in relation to optimal low density lipoprotein cholesterol combined with hypertriglyceridemia: is there a difference by gender? Ann Epidemiol. 2011; 21:807-14.

Lehninger AL, Cox M, Nelson DL. Lehninger's Principles of Biochemistry. W H Freeman and Company; 2008.

Kronenberg HM, Melmed S, Polonsky KS. Disorders of Lipid metabolism. William Textbook of Endocrinology. Saunders Elsevier; 2008.

Andiran N, Celik N, Andiran F. Homozygosity for two missense mutations in the leptin receptor gene (P316:W646C) in a Turkmenian girl with severe early onset obesity. J Pediatr Endocrinol Metab. 2011; 24:1043-45.

Ahmed N, Anwar W, Waqas H. Obesity, hyperlipidemia and hyperuraecemia in young and old hypertensive patients. J Ayub Med Coll Abbottabad. 2009; 21:53-6.

Visavadiya NP, Narasimhacharya AVRL. Hypolipidemic and antioxidant activities of Asparagus racemosus in hypercholesteremic rats. Indian J Pharmacol. 2005; 37:376-80.

McEwen BS, Stellar E. Stress and the individual: mechanisms leading to disease. Arch Intern Med. 1993; 153:2093-2101.

Mokdad AH, Ford ES, Bowman BA. Prevalence of obesity, diabetes and obesity related health risk factors. JAMA. 2003; 289:76-9.

Silverstein M, Palmer J, Polinsky MS. Risk factors for hyperlipidemia in long-term pediatric renal transplant recipients. Pediatr Nephrol. 2000; 14:105-110.

Boericke W. Materia medica. Narayana Publications; 2007.

Yarnell E. Botanical medicines for the urinary tract. World J Urol. 2002; 20:285-93.

Ara J, Sultana V, Qasim R. Biological activity of Spatoglossum asperum: a brown alga. Phytotherapy research. 2005; 19:618-23.

Lateef T, Rukash H, Bibi F. Effect of Convallaria majalis on kidney function. JDUHS. 2010; 4:94-7.

Qureshi SA, Nawaz A, Udani SK. Hypoglycemic and hypolipidemic activities of Rauwolfia serpentina in alloxan-induced diabetic rats. Int J Pharmacology. 2009; 5:323-26.

Qureshi SA, Kamran M, Asad M. A preliminary study of Santalum album on serum lipids and enzymes. Global Journal of Pharmacology. 2010; 4:71-4.

Richard F, Clark MA, Luigix C. Hyperlipidemia. Lippincott's illustrated review: Pharmacology. Lippincott Williams and Wilkins; 2009.

Rang HP, Dale MM, Ritter JM. Pharmacology. Churchill Livingstone Publishers; 2003.

Qureshi SA, Udani SK. Hypolipidemic activity of Rauwolfia serpentina Benth. Pakistan Journal of Nutrition. 2009; 8:1103-6.

Posta TL, Gebauer SK, Meyer G. Diet and the control of blood lipids. Nutritional Health, Strategies for Disease. Humana Press; 2006.

Smith JRSC, Jackson R, Pearson TA. Principles for national and regional guidelines on cardiovascular diseases prevention: A scientific statement from the world Heart and Stroke Forum. Circulation. 2004; 109:3112-21.

Bahramika S, Yazdanparast R. Effect of hydroalcoholic extracts of Nasturtium officinale leaves on lipid profile in high fat diet rats. J Ethanopharmaco. 2008; 115:116-21.

Bishop ML, Fody EP, Schoeff L. Lipids and lipoproteins. Clinical chemistry, Principles, procedures, correlations. Lippincott Williams and Wilkins; 2005.

Ahmed N. Abnormalities of lipid metabolism. Clinical Biochemistry. Oxford University press; 2011.

Sukla R, Gupta S, Gambhir JK. Antioxidant effect of aqueous extract of the bark of Ficus bengalensis in hypercholesterolaemic rabbits. J Ethanopharmacol. 2004; 92:47-55.

Wang L, Zhang XT, Zhang HY. Effect of Vaccinium bracteatum Thumb. leaves extract on blood glucose and plasma lipid levels in streptozotocin-induced diabetic mice. Journal of Ethanopharmacology. 2010; 130:465-69.

Chang Y, Ryu S, Sung E. Higher concentrations of alanine aminotransferase within the reference interval predict nonalcoholic fatty liver disease. Clinical Chemistry. 2007; 53:686-92.

Clark JM, Brancati FL, Diehi AM. The prevalence and etiology of elevated aminotransferase levels in United States. Am J Gastroenterology. 2003; 98:960-7.

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Published

2012-06-08

How to Cite

Lateef, T. ., Riaz, A. ., Zehra, A. ., & A Qureshi, S. . (2012). Antihyperlipidemic effect of Adonis vernalis. Journal of the Dow University of Health Sciences (JDUHS), 6(2), 47–51. Retrieved from https://mail.jduhs.com/index.php/jduhs/article/view/1503

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