Effect of Convallaria majalis on Kidney Function

Authors

  • Tooba Lateef Department of Biochemistry, Jinnah University for Women, Karachi-74600, Pakistan.
  • Hafsa Rukash Department of Biochemistry, Jinnah University for Women, Karachi-74600, Pakistan.
  • Faiza Bibi Department of Biochemistry, Jinnah University for Women, Karachi-74600, Pakistan.
  • Muhammad Bilal Azmi Dow College of Pharmacy, Dow University of Health Sciences, Karachi-74200, Pakistan.
  • Shamim Akhtar Qureshi Department of Biochemistry, University of Karachi, Karachi- 75270, Pakistan.

Keywords:

Glomerular filtration, kidney, uric acid, creatinine, hypouricemic activity

Abstract

Objective:

To evaluate the effect o f Convallaria majalis on kidney function. The kidneys are vital organs thatperform a variety of important functions in our body. Primary and secondary causes o f kidney diseases producechanges in glomerular filtration rate that m ay leads to kidney failure. Blood parameters such as uric acid andcreatinine are used to assess kidney function. C. majalis (CM) commonly called as Lily o f the valley is aHomoeopathic remedy having valuable action on heart and also has diuretic action.

Methods:

In the present study, the effect o f CM was investigated on serum uric acid and creatinine, byadministrating orally 70% alcoholic extract o f CM (10 and 50 mg/kg), simvastatin (20 mg/kg), 0.05%dimethylsulphooxide (DMSO, 1ml/kg) and distilled w ater (1ml/kg) to test (A & B groups), positive, negativeand control rabbits respectively for 14 days consecutively once in a day. 

Results:

Out of two tested doses, 10 mg/kg o f CM produced significant decrease in uric acid levels from 10.978.40mg/dL in test rabbits (Test A) when compared with control, negative & positive control groups (p<0.05).However, the same dose o f extract showed no effect on serum creatinine levels. 

Conclusion:

According to the data, alcoholic extract o f CM @ 10mg/kg was found as a significant hypouricemicagent.

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Published

2010-12-12

How to Cite

Lateef, T. ., Rukash, H. ., Bibi, F. ., Bilal Azmi, M. ., & Akhtar Qureshi, S. . (2010). Effect of Convallaria majalis on Kidney Function. Journal of the Dow University of Health Sciences (JDUHS), 4(3), 94–97. Retrieved from https://mail.jduhs.com/index.php/jduhs/article/view/1329

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Section

Original Articles