Association of BMI with Testosterone in Infertile Males among Local Population

Authors

  • Fahmida Khatoon Department of Biochemistry, Dow University of Health Sciences, Karachi, Pakistan.
  • Farhan Essa Abdullah Department of Microbiology and Immunology, Dow University of Health Sciences, Karachi, Pakistan.
  • Atif Mahmood Department of Physiology, Dow University of Health Sciences, Karachi, Pakistan.
  • Mukarram Ali Department of Forensic Medicine, Dow International Medical College, Dow University of Health Sciences, Karachi, Pakistan.
  • Nadeem Alum Department of Biochemistry, Dow University of Health Sciences, Karachi, Pakistan.
  • Nazrul Hasnain Department of Biochemistry, Dow University of Health Sciences, Karachi, Pakistan.

Keywords:

Male Infertility, BMI, Testosterone, Azoospermia, Oligospermia

Abstract

Objective

To ascertain association of raised BMI with Testosterone levels among infertile males.

Methods

A cross sectional study was conducted from April 2010 to March 2011. Sample size was 300 males (147 infertile and 153 healthy fertile control subjects) aged 30 and 60 years, selected from the Jinnah Postgraduate Medical Center (JPMC), Aziz Medical Center and Abbasi Shaheed Hospital, Karachi. All the subjects were grouped to BMI criteria (Ascian  pacific region for WHO). They were selected by purposive sampling after a detailed medical history and physical examination. Semen analysis was done and blood samples were collected for serum Testosterone levels. Data was analyzed via SPSS 16.0 by using Analysis of Variances (ANOVA) and independent t test to compare the means and to observe sensitivity of tests and to evaluate the significant association with in the group.

Results

A significant negative correlation existed between Testosterone and BMI .Raised BMI appear to have an association with male infertility with the reduction in Testosterone levels.

Conclusion

Obesity is confirmed as risk factor for male infertility in local population.

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References

Kolettis PN. Evaluation of the subfertile man. American family physician. 2003; 67:2165-73.

Dohle GR, Jungwirth A, Kopa Z, Giwercman A, Diemer T, Hargreave TB. EAU guidelines on male infertility. Urology. 2005; 48:703-11.

Rowe PJ, Comhaire FH. WHO manual for the standardized investigation, diagnosis and management of the infertile male. Cambridge University Press; 2000.

Habbema J, Collins J, Leridon H, Lvers J, Lunenfeld B, teVelde E. Towards less confusing terminology in reproductive medicine. a proposal. Human Reproduction. 2004; 19:1497.

Bhasin S, De Kretser DM, Baker HW. Clinical review 64: Pathophysiology and natural history of male infertility. Journal of Clinical Endocrinology & Metabolism. 1994; 79:1525-29.

Griffin D, Finch K. The genetic and cytogenetic basis of male infertility. Human Fertility. 2005; 8:19-26.

Kay VJ, Barratt CLR. Male obesity: impact on fertility. The British Journal of Diabetes & Vascular Disease 2009; 9:237-41.

Tsai EC, Boyko EJ, Leonetti DL, Fujimoto WY. Low serum T level as a predictor of increased visceral fat in Japanese-American men. International journal of obesity and related metabolic disorders: Journal of the International Association for the Study of Obesity. 2000;

:485-91.

Lementowski PW, Zelicof SB. Obesity and osteoarthritis. The American journal of Orthopedics. 2008; 37:148-51.

Shaffer EA. Epidemiology of gallbladder stone disease. Best Practice & Research Clinical Gastroenterology 2006; 20:981-96.

Yassin AA, Saad F, Gooren LJ. Metabolic syndrome, T deficiency and fertile dysfunction never come alone. Andrologia 2008; 40:259-64.

Aggerholm AS, Thulstrup AM, Toft G, Ramlau-Hansen CH, Bonde JP. Is overweight a risk factor for reduced semen quality and altered serum sex hormone profile? Fertility and sterility. 2008; 90:619-26.

Simpson E, Rubin G, Clyne C, Robertson K, O'Donnell L, Davis S, et al. Local estrogen biosynthesis in males and females. Endocrine-related cancer. 1999; 6:131-7.

Giagulli VA, Kaufman JM, Vermeulen A. Pathogenesis of the decreased androgen levels in obese men. Journal of Clinical Endocrinology & Metabolism. 1994; 79:997- 1000.

Pauli EM, Legro RS, Demers LM, Kunselman AR, Dodson WC, Lee PA. Diminished paternity and gonadal function with increasing obesity in men. Fertility and sterility. 2008; 90:346-51.

World Health O. WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction. World Health Organization. Cambridge University Press; 1999.

Bieth E, Bujan L, Massat G, Pontonnier F, Mieusset R. Congenital bilateral absence of the vas deferens: clinical characteristics, biological parameters, cystic fibrosis transmembrane conductance regulator gene mutations, and implications for genetic counseling. Fertility and sterility. 2000; 74:1164-74.

Maheshwari A, Stofberg L, Bhattacharya S. Effect of overweight and obesity on assisted reproductive technology—a systematic review. Human Reproduction Update. 2007; 13:433.

Zaadstra B, JC Van Noort , Velde Et, JD Habbema JD, Vrieswijk B. Fat and female fecundity: prospective study of effect of body fat distribution on conception rates. BMJ 1993; 306:487.

Akpinar E, Bashan I, Bozdemir N, Saatci E. Which is the best anthropometric technique to identify obesity: body mass index, waist circumference or waist-hip ratio? Collegium Antropologicum. 2007; 31:387.

Deurenberg P, Weststrate JA, Seidell JC. Body mass index as a measure of body fatness: age-and sex-specific prediction formulas. British Journal Nutrion. 1991; 65:105-14.

Christiane Wittemer, Ohl J, Marc Bailly, BettaharLebugle K, Nisand I. Does Body Mass Index of Infertile Women Have an Impact on IVF Procedure and Outcome? Journal of Assisted Reproduction and Genetics 1999; 17:547-52.

Chavarro JE, Toth TL, Wright DL, Meeker JD, Hauser R. Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormone levels among men attending an infertility clinic. Fertility and Sterility. 93:2222-31.

Young RA, Frink R, Longcope C. Serum T and gonadotropins in the genetically obese male Zucker rat. Endocrinology. 1982; 111:977.

Kley HK, Solbach HG, McKinnan JC, Krüskemper HL. T decrease and oestrogen increase in male patients with obesity. Acta Endocrinologica. 1979; 91:553.

Osuna C JA, Gomez-Perez R, Arata-Bellabarba G, Villaroel V. Relationship between BMI, total T, sex hormone-binding-globulin, leptin, insulin and insulin resistance in obese men. Systems Biology in Reproductive Medicine. 2006; 52:355-61.

Tchernof A, Després JP, Bélanger A, Dupont A, Prud'homme D, Moorjani S, et al. Reduced T and adrenal C19 steroid levels in obese men* 1. Metabolism. 1995; 44:513-9.

MacDonald AA, Herbison GP, Showell M, Farquhar CM. The impact of body mass index on semen parameters and reproductive hormones in human males: a systematic review with meta-analysis. Hum Reprod Update; 16:293-311.

Kley HK, Edelmannand HL. Relationship of plasma sex hormones to different parameters of obesity in male subjects. Metabolism.1980; 29:1041-5.

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Published

2012-06-07

How to Cite

Khatoon, F. ., Essa Abdullah, F. ., Mahmood, A. ., Ali, M. ., Alum, N., & Hasnain, N. . (2012). Association of BMI with Testosterone in Infertile Males among Local Population. Journal of the Dow University of Health Sciences (JDUHS), 6(2), 62–65. Retrieved from https://mail.jduhs.com/index.php/jduhs/article/view/1510

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Original Articles